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Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells

(2018) 315:C34356

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Our findings show the effect of depletion of existing intracellular GSH and inhibition of GSH biosynthesis with a BSO-based peptide derivative, which provides a new strategy for in situ construction of selective and efficient nanomedicine for intracellular GSH regulation and tumor inhibition

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Glutathione removes peroxides from membrane lipids and serves as a substrate for H 2 O 2 reduction to H 2 O via the action of glutathione peroxidase