All authors had full access to study data, contributed to the drafting and revision of the manuscript and approved the manuscript for submission
Dot plots show the CHIP analysis results on CREM binding to the promoter of Gpx4 from neutrophils (n = 6) with indicated treatment: IFN- (10^5 U ml -1 ), anti-IFNAR (10 g ml -1 ), SLE IgG (2.4 g L -1 ) or SLE sera with IgG depletion
However, CagriBB has equivalent potency to Cagri, in CRE-reporter assays in mammalian cells expressing AMY 3 Rs (Supplementary Table 4), suggesting there is negligible impact of this rotamer difference
The DAC modification significantly prolongs the half-life of the peptide, providing more consistent stimulation of GH release. Teichman et al., Journal of Clinical Endocrinology & Metabolism Modified GRF (1-29) aka CJC-1295 without DAC: This shorter-acting version has a half-life of 30 minutes to 2 hours , mimicking natural GH pulses more closely
A., Aberman, H
Angiogenesis (new blood vessel formation) signaling