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5.2.4 Novel pharmacotherapies and combination treatment As a multifactorial degenerative disease, OA often responds poorly to single-target therapies ( Increasingly, ferroptosis is recognized as central to the multifaceted and dynamic pathophysiology of OA

49, 50, 51, 52, 53 Additionally, intestinal permeability has been associated with mental illness including schizophrenia and depression

In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration