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10.1016/S0928-4257(00)00212-6 109 SekinoA.OhataH.Mano-OtagiriA.AraiK.ShibasakiT

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Renal cells in the context of ADPKD exhibit a wide range of metabolic abnormalities, including the decreased expression of system Xc- and reduced activity of GPX4, which are the necessary conditions and typical characteristics of ferroptosis [252, 253]