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This treatment enhanced insulin resistance by inhibiting the NF-B/NLRP3 activation pathway, thereby altering the levels of gut flora metabolites 4-hydroxyphenylacetic acid and 3- (4-hydroxyphenyl) propionic acid (Yao et al., 2022)

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Obese-hypertensive rats presented with increased levels of serum inflammatory cytokines when compared with control (130)

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These results suggest a direct involvement of excess HBP flux in desensitizing the fusion between GLUT4-containing intracellular vesicles and the plasma membrane

A high-throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway