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4.1 Oxidative stress and male infertility Cellular oxidative stress can result from an increase in the production of reactive oxygen species (ROS), such as hydroxyl radicals (OH), superoxide anions (O2), and hydrogen peroxide (H2O2) ( Sperm cells are among the first to exhibit susceptibility to oxidative damage

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found that melittin therapy enhances the anti-inflammatory ability of the proteasome in the central nervous system (CNS) of Amyotrophic Lateral Sclerosis (ALS) model mice (Yang et al., 2011)

In the presence of redox-active metals, particularly copper, GSH serves as a physiological reducing equivalent donor within these coupled reactions, contributing to the generation of Cu + from Cu 2+ under defined chemical or catalytic conditions

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