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The contradictory response of glutathione gel in the treatment of melasma in different studies may be attributed to the difference in stability, absorption, penetration of glutathione and affected by the different vehicle (soap, cream, gel or lotion) rather than the efficacy of glutathione itself
In TRIUMPH-4, dysesthesia (abnormal sensations: tingling, prickling, burning, numbness) was reported by 8,8% of participants in the 9 mg dose range and 20,9% of participants in the 12 mg dose range
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