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In intestinal regions characterized by phasic motor patterns (small and large intestines), ICC-driven slow waves bring the membrane potential to the threshold of CaV1.2 channels, triggering action potentials (Morgan et al., 1981

The clear separation between treatment and placebo groups (5272 vs 9.6 hairs) leaves little room for doubt about efficacy

Although no randomized trials exist, the uniformity of observational data has led GeneReviews and European neurometabolic taskforces to issue class I recommendations for immediate high-dose riboflavin upon molecular diagnosis (14)

Pharmaceuticals (Basel)

Tyrosinase contains a coupled binuclear copper (CBC) active site that binds dioxygen to form an oxy-tyrosinase intermediate which then binds the substrate (tyrosine) and carries out its monooxygenation

For use in controlled laboratory conditions only