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A 2018 attempt by an independent lab to reproduce the headline neurotrophic effect in vitro reportedly produced mixed results, which is a typical finding when independent groups try to replicate striking preclinical findings

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The research on MOTS-c dosage has matured considerably since the original mouse studies, though human clinical trials remain limited in number

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The speciation (i.e., neutral and ionized forms) must be considered because the neutral form is often easily absorbed by organisms 7