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Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

These are best treated as auxiliary hypotheses rather than primary mechanism, as the experimental support is narrower than for the VEGFR2-eNOS axis

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Tabor, H., Tabor, C

3-PH can obtain an amino group from glutamate and form 3-phosphoserine (3-PS) through phosphoserine transaminase (PSAT) followed by dephosphorylation through serine phosphatase (PSPH) to finally produce serine (Figure 1)