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Older GLP-1 receptor agonists like liraglutide (Victoza, Saxenda) showed somewhat larger heart rate increases in trial data compared to semaglutide

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Together, these effects help people feel more energised, resilient, and balanced in both body and mind

10.1007/s00726-017-2409-2 [DOI] [PubMed] [Google Scholar] Ham D

In the SURPASS-2 trial, which compared it head-to-head against semaglutide 1 mg over 40 weeks, tirzepatide lowered HbA1c by about 2.0 to 2.3 percentage points across its 5, 10, and 15 mg doses, versus roughly 1.9 points for semaglutide, with greater weight loss as well

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