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Single immune checkpoint inhibitors (sICIs) are frequently reported to cause adverse events (AEs) such as rash, jaundice, hypothyroidism, pneumonitis, neutropenia, and in some cases, necessitate medication discontinuation ( Although dICIs are currently approved for various cancer indications and have demonstrated superior efficacy compared to sICI therapy, their safety profile and limitations warrant careful consideration ( Materials and methods Data source The original data utilized for our data mining were sourced exclusively from the FAERS database available on the official FDA website

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