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The presence of compounds like melittin, phospholipase A2, and biogenic amines in BV has been a subject of interest, with melittin, in particular, being a major toxin known for its cytotoxic effects (Shi et al., 2022)
For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)
No conclusions of comparative efficacy and safety should be drawn
