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They can not only serve as representative readings of the functional output of microorganisms, but also may act as potential remote immune regulators in the intestinal-articular axis by affecting the energy metabolism and barrier balance of the intestinal epithelium, and regulating the activation threshold and cytokine network of immune cells (Kasubuchi et al., 2015)
It also partially activates the expression of GSH, GPX4, and SLC7A11, and inhibits the expression of ROS and IL-18 [156]
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Dar found that when PA infected epithelial cells, M1-activated macrophages expressed iNOS/NO in the host immune cells, which could make the cells resistant to ferroptosis [47]
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