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Hypoxia-inducible factors (HIFs) orchestrate adaptive transcriptional programs that enhance glycolysis, angiogenesis, acidosis, and survival signaling, while metabolic rewiring toward aerobic glycolysis, glutaminolysis, and lipid metabolism supports rapid proliferation and therapeutic resistance

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Dai Y, Huang K, Zhang B, Zhu L, Xu W

Under certain conditions, GGT-mediated degradation of GSH facilitates the formation of reactive oxygen species, causing lipid peroxidation of cell membranes, which ultimately leads to apoptosis or necrosis of gastric epithelial cells in vitro 15

5 Conclusion The antioxidant effects of Spirulina platensis aqueous extract (SPAE) contributed to regulating biochemical parameters, including liver enzymes and lipid profiles, in male rats subjected to dexamethasone-induced oxidative stress