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Importantly, glucose metabolism and insulin sensitivity were either unchanged or slightly improved, contrasting with the diabetogenic effects of growth hormone

As pointed out [60], it has to be the counteraction of the reduced capillary perfusion pressure, increased cerebral blood volume, venous flow obstruction, increased intracranial pressure and blood-brain barrier disruption, resulting in a decreased cerebral blood flow [60]

Thus the microstructure of the alloy is uniform throughout the sample