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In contrast, our present study suggests that HFD feeding plus hepatic insulin resistance is involved in the alterations in BA composition

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Carlson and Prusiner, 2021)

IL-6, which is also increased in obesity (176, 183) can stimulate lipolysis (184) and cause hyperglycemia and hepatic insulin resistance in rats (183) and requires intact JNK signaling in macrophages (183) to promote diet-induced insulin resistance (185)

Both are studied to understand different aspects of the peptides efficacy and mechanism

Peptides are short chains of amino acids that function as signaling molecules in your body