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AOP Development Strategy Context This AOP was developed for the project "CHRONIC TOXICITY OF PESTICIDES IN DRINKING WATER IN PARABA (TRIGGER): IDENTIFYING THE TRIGGERS OF A SILENT EPIDEMIC," financed by the "Fundao de Apoio Pesquisa do Estado da Paraba (FAPESQ-PB)." The project aims to understand how oxidative stress and reproductive toxicity can be triggered in animals by aquatic pollutants, such as atrazine Strategy The first step in developing this AOP was to conduct a literature review to gather toxicological data on the herbicide atrazine's impact on aquatic vertebrates in relation to oxidative stress and reproductive toxicity

PloS one 8 (6), e67215

8 For example, blood uric acid levels in humans are normally about six times that of vitamin C, and about 10 times the levels in other mammals

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Labs In those with established toxicity, or those predicted to develop toxicity based on history and initial serum acetaminophen concentration, additional laboratory tests should include the following: Liver function tests (AST/ALT, INR, bilirubin)

Lubricates Joints to Promote Comfort and Flexibility*