GnRH agonists, such as leuprolide, initially induce a flare effect, subsequently leading to pituitary desensitization and suppression of FSH and LH
Glutathione, as the master antioxidant and essential substrate for the GPx enzyme family, sits at the absolute center of this protection system
Because the cells are supplied with the raw, rate-limiting materials rather than the finished product, they can auto-regulate their own glutathione synthesis
Regarding therapeutic strategies, interventions based on animal models (e.g., iron chelators, antioxidants) face a dual dilemma of target specificity and safety
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M.PorterfieldD