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Therefore, the infiltration of helper T cells (CD4 + ) and cytotoxic T cells (CD8 + ) in tumor tissues was further investigated

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Activation of Caspase-8 promotes Caspase-3-mediated apoptosis (Legembre et al., 2002), while inhibiting the RIPK1/RIPK3 axis (necroptosis) (Newton and Manning, 2016) and the NLRP3/Caspase-1 axis (pyroptosis) (Frank and Vince, 2019)

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