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While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)

Pharmacokinetic and Pharmacodynamic Evaluation : Assessing absorption, distribution, half-life, and exposureresponse relationships for long-acting peptide analogues, including the effects of lipidation and albumin binding