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6 month old male APP/PS1 mice and wild-type C57 mice were used for the purpose of this study

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The accumulation of amyloid plaques is a pivotal factor associated with subsequent neuronal toxicity in AD pathogenesis, eventually associated with synaptic dysfunction and more severe cognitive deficits [38]

It has a high affinity for copper ions (Cu), forming a stable and biologically active complex that may support coppers bioavailability and intracellular activity

However, the Rumack-Matthew nomogram is used the same way in pediatric patients as in adult patients