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Structure-based mechanisms of 23-cGAMP intercellular transport in the cGASSTING immune pathway

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In yeast, Ohsumis and Klionskys laboratories first identified that ATG32 acts as the mitophagy-specific receptor, which directly interacts with the selective autophagy adaptor ATG8 via an ATG8-interacting motif (AIM) and ATG11 to form the nascent autophagosome (Okamoto et al., 2009)