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Author Contributions Conceived and designed the experiments: BM SD ATP

In line with our observation, a previous study 40 found that the inflammatory profile of pericardial fluid was different from that of serum in IHD, and IHD potentiated the profibrotic activity of pericardial fluid compared with non-IHD (valvular disease), suggesting a greater impact of IHD on local microenvironment surrounding the heart

10.1038/sj.gt.3303094 Gene Ther