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The primary difference is that women may be more sensitive to side effects and should be more cautious when titrating to the advanced range

Moreno-Navarrete, J

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Conclusions We have identified plasma mGSTP1 levels as a potential prognostic marker in men with CRPC, raised the hypothesis that plasma mGSTP1 -free DNA levels could be a potential surrogate measure of therapeutic efficacy for cytotoxic chemotherapy and corroborated these findings in an independent Phase II cohort

This is caused by a brief release of histamine and rapid vasodilation