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& Sprinchorn, A

as a key regulator of mitochondrial biogenesis, PGC1 enhances mitochondrial function in myoblasts, supplies sufficient energy for differentiation, and regulates the transcription of myogenic genes to accelerate myotube maturation

This allows assessment of tolerance before increasing to standard therapeutic doses of 1-2mg daily

(Tesamorelin is also prescribed to treat HIV-associated lipodystrophy, or excess abdominal fat accumulation resulting from antiretroviral therapy

The single-target competitor most people know is semaglutide (Ozempic, Wegovy), which only activates GLP-1

The compound can be used by women, though effects specific to female physiology have not been specifically studied