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Peptide therapy should be approached thoughtfully

Those who suffer from Imerslund-Grasbeck disease , a genetic disorder, are unable to absorb dietary B12

Hydroxocobalamin injections are the UK first-line treatment, administered intramuscularly to ensure reliable B12 delivery independent of gut absorption

But an assortment of unapproved peptides ranging from injectables, creams, capsules, and nasal sprays are trending in an unregulated marketplace after the Biden administration in 2023 prohibited them from being manufactured, finding safety risks and lack of human studies to support their use

Ko et al., 2007

Pharmaceutics 16 (2), 227