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Of note, the commercial Iscoves Modified Dulbeccos Medium (IMDM) and Serum Free Expansion Medium (SFEM), which were used as the basal medium for erythroblast cultures, contain a supraphysiological concentration of cystine at 292 M as compared to physiological plasma concentration of 4075 M cysteine in SCD patients, which decreased further to 3060 M during vaso-occlusive pain episodes 36

The difference is the delivery format and presentation, not the compound itself: the spray arrives pre-filled, while the BPC-157 vial is supplied as a dry powder

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Aberrant decidual ferroptosis may result in defective implantation or impaired immune function

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doi: 10.15171/apb.2016.04