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Siegel, D

& Xu, C

535 p53 can accelerate ferroptosis and the development of atherosclerosis by binding to SLC7A11, preventing the synthesis of GSH, and increasing the hydrolysis of GSH and the production of ROS by activating glutaminase 2

Originally studied for gut health, its now widely used to support joint, muscle, tendon, and ligament recovery

We next asked the question whether glutathione biosynthesis from dietary glycine and cysteine is regulated by cellular glutathione demand

Constitutively stabilized NRF2 also promotes cell proliferation, as NRF2 knockdown inhibits the proliferation of human lung cancer cell lines (Singh et al., 2008)