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In an initial attempt to transform the highly active AngIV analog, Nle 1 -AngIV, into an effective drug, we evaluated the procognitive activity of a series of C-terminal truncated peptides derived from Nle 1 -AngIV (Benoist et al., 2011)

Proper cycling of 5-amino-1MQ prevents tolerance development and allows natural NNMT function to reset