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Tendons and ligaments: Have low vascularity (limited blood flow) Depend heavily on collagen alignment and remodeling Heal slowly and often incompletely Are prone to scar tissue and reinjury Traditional treatmentsrest, physiotherapy, NSAIDs, corticosteroid injectionscan reduce pain but often do not improve tissue quality

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FOXO4-DRI Treatment Does Not Markedly Improve the Regenerative Potential of PDL9 Chondrocytes The regenerative potential of PDL9 chondrocytes after FOXO4-DRI treatment was assessed by 3D pellet culture