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The new guidelines from the British Committee for Standards in Haematology state that you should treat based on symptoms alone

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If your reconstituted tirzepatide accidentally freezes (perhaps placed too close to the back of a very cold fridge or left in a freezer by mistake), discard it

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What the Research Shows In the STEP 1 clinical trial, published in Diabetes, Obesity and Metabolism (Wiley), participants receiving semaglutide 2.4 mg once weekly achieved an average weight loss of 17.3% over 68 weeks, compared with 2.0% in the placebo group