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Researchers know that people who have less methylfolate available because of the MTHFR gene mutation have a higher risk of heart attack and stroke

This finding was consistent for cardiovascular mortality (HR 0.90, 95% CI from 0.50 to 1.61) and all-cause mortality (HR 0.80, 95% CI from 0.51 to 1.25)

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(PubMed) Meydani SN, Meydani M, Blumberg JB, et al

One explanation is the thought that curtailing IGF-1 levels increase the expression of other genes that are involved in stress resistance, particularly oxidative damage

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