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Funding National Natural Science Foundation of China, 82405296, 82274483, 82305158 Ethics declarations Ethics approval and consent to participate The animal study protocol was approved by the Animal Care and Use Committee (ACUC) of [Nanjing University of Traditional Chinese Medicine], protocol number [ACU240404]

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Weight reduction: In the phase 2 trial, cagrilintide 4.5 mg weekly produced approximately 10.8% body weight loss over 26 weeks versus 3.0% with placebo [4]

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