Overweight or obesity (BMI 30-plus, or 27-plus with a weight-related condition) where weight loss is the goal and there is no diabetes driving the choice
First, KEAP1 has been shown to have complex interactions with various other proteins besides NRF2 (Hushpulian et al., 2021) and concerns about potential side effects arise from the diverse array of cellular processes covered by KEAP1 interactor proteins, involving DNA replication, cytoskeletal dynamics, transcription, and apoptosis
Among the seleno-GPxs, GPx2 and GPx4 have the highest priority for selenium utilization, suggesting the important roles played by them in maintaining the cellular antioxidant defense mechanisms [8, 25]
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Sigmund CD
