All their patients with pneumonia caused by SARS-CoV-2 who develop SRF display hyper-inflammatory responses with two features: over-production of pro-inflammatory cytokines by monocytes and dysregulation of lymphocytes characterized by CD4 lymphopenia and subsequently B cell lymphopenia ( However, inhibiting TNF has a direct effect in reducing the level of IL-6 and IL-1 along with adhesion molecules and vascular endothelial growth factor (VEGF) in RA patients ( During SARS-CoV-2 infection, aggressive inflammatory response and cytokine storm contribute to severe systemic tissue damage and mortality
In a high-oxidative-stress environment rich in superoxide, NO is rapidly converted to pro-ferroptotic ONOO
Additionally, a study has shown that dexamethasone (DEX) induces glucocorticoid-induced osteonecrosis and MC3T3-E1 cells ferroptosis by regulating P53/SLC7A11/GPX4 axis (43), indicating that this pathway may be a potential strategy for treating osteoporosis
Arrese, E
doi:10.2174/157015909787602788 Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, ONeil GN, BG-12 Phase IIb Study Investigators (2008) Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
J Dermatol Sci 2010;58:85-90
