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This is of relevance because when regeneration is advanced and the anti-inflammatory response is predominant [75], a second peak of hyperalgesia can be observed due to tissue remodeling and the appearance of newly regenerated sensory fibers [76]

These combination data support the hypothesis that dual targeting of amylin receptor and GLP-1 receptor pathways which engage anatomically and mechanistically distinct neural circuits can produce synergistic metabolic outcomes in preclinical and clinical models

Wagoner RM, Eichner A, Bhasin S

In the study by Gayatri et al

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