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The CG methylation is thought to alter chromatin density and DNA accessibility by blocking the binding of TFs to their cognate DNA sequences and/or increasing the recruitment of the methyl-binding proteins and histone deacetylases (Bird, 2002)

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Because eflornithine does not destroy follicles, growth gradually returns to baseline about eight weeks after discontinuation

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Beyond that, FDA official Russell Wesdyk said a "foundational challenge" with BPC-157 and all the substances under consideration is that the agency can't actually define what they are