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doi:10.3390/jcm14062020 Li Z, Weng X

Work with a licensed healthcare provider for proper medical oversight

Herbal supplements with hypoglycemic effects should be used cautiously, as they may potentiate tirzepatide's glucose-lowering action and increase hypoglycemia risk, especially when combined with insulin or sulfonylureas

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In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate