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Importantly, none of these clinical trials were adequately powered, well-designed, or replicated to confirm the efficacy of these interventions conclusively

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10.1038/sj.ijo.0802881 Int J Obes

Several studies have shown that LA supplementation significantly decreases hepatic lipid accumulation and function in a normal MCD diet and a hypercaloric MCD diet (Table 6)

Int J Med Rev Case Rep 2018

Under obese conditions, LEPs regulatory effects on insulin sensitivity become attenuated, contributing to insulin resistance