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For individuals with digestive sensitivities, those taking acid-reflux medications, or anyone on a plant-based (vegan/vegetarian) diet, absorbing enough B12 through food or pills is virtually impossible

Second, larger vials (10-20 mg) generally get the same 2 mL to keep concentration high enough that GLP-1 weekly doses don't require uncomfortably large injection volumes

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Other risk factors include age over 50 (reduced gastric acid impairs absorption), proton pump inhibitor use, prior gastric surgery, and Type 1 diabetes

How a B12 injection works Vitamin B12, also called cyanocobalamin, is essential for red blood cell production, nerve function, energy metabolism and the synthesis of DNA