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In addition to metabolites of carbohydrate and lipid metabolism, amino acids (AAs) have emerged as putative biomarkers for the detection of joint diseases [8], and there are OA-related alterations in the profiles and metabolism of, for instance, glutamic acid and arginine family AAs [9]

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In RA patients, there is a noticeable increase in certain key cytokines within the synovial fluid, specifically IL-2, IL-3, and IL-19/IL-20

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