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Patients with visceral hypersensitivity (VH) have also been shown to harbor a dysbiotic gut microbiota [47], and transplanting fecal microbiota from these patients to germ-free mice produced a similar phenotype in the animals

Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

Significant healing improvements develop over four to six weeks with consistent use

risk ratio [RR], 0.37

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