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Subsequently, arachidonic acid is esterified into phosphatidylethanolamine-arachidonic acid under ACSL4 catalysis, promoting the accumulation of LPO that drive ferroptosis in OA (Cao et al., 2025)

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doi: 10.1371/journal.pone.0084943

As the medical community seeks effective treatments for these persistent and often debilitating symptoms, two promising molecules have come to the forefront: NAD+ (Nicotinamide Adenine Dinucleotide) and glutathione

Apart from these, other factors are also implicated such as phototoxic drugs, anticonvulsant medications, and certain cosmetics.[] Melasma is resistant to treatment and has a high rate of recurrence

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