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When the body detects these pathogens, the immune system launches a massive defensive response, releasing pro-inflammatory cytokines like IL-6 and TNF- in what is sometimes called a "cytokine storm." While this inflammatory response is necessary to destroy the virus, it comes at a steep metabolic cost

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GSH + amino acid -Glu-amino acid +CysH-Gly (amino group transfer) GSH + H2O Glu +CysH-Gly (hydrolysis) GSH + GSH -Glu-GSH +CysH-Gly (amino group transfer) 3

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The ligands were bound to D106 according to the crystal structures using the [intermolecular_interactions] block of GROMACS with a bond length of 0.185 nm, a force constant of 10 5 kJ mol 1 nm 2 and bond type 6