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HCG displays notably greater cAMP/PKA-mediated steroidogenic and pro-apoptotic potential compared to LH, and Leydig cell in vitro exposure to hCG results in qualitatively similar but quantitatively distinct cAMP/PKA and pERK1/2 activation patterns

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4.1 Effects on the male reproductive system Melatonin significantly improves the status of the male reproductive system, acting through the hypothalamicpituitarygonadal (HPG) axis to regulate the secretion of reproductive hormones, primarily GnRH and luteinizing hormone (LH) (71)

Deficiencies of vitamin B12 have also been linked to degenerative brain function and cognitive decline