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Endothelial function The inner lining of blood vessels, known as the vascular endothelium, plays an important role in the maintenance of cardiovascular health

Arch Med Res 55(5):103016

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GSH is negatively charged at physiological pH so it is unable to cross both the outer mitochondrial membrane (OMM) and the inner mitochondrial membrane (IMM)

GSH is the thiol source for gliotoxin, which is essential for its function, and deletion of gliG results in the complete abrogation of gliotoxin biosynthesis (Figure 3)

While RSL3 promotes ferroptosis via inhibition of GPX4, it also appears to enhance tumor cell DNA damage