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Future studies demonstrated that KEAP1 does not passively sequester NRF2 in the cytosol, but actively functions as a ubiquitin ligase, leading to ubiquitination and proteasomal degradation of NRF2 (Zhang and Hannink, 2003)

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Moreover, previous studies have shown, that defective PINK expression and impaired mitochondrial dynamics favor reduced sensitivity for insulin and result in defective adipogenic differentiation potential of ASC

LiMCaoFWangWMaYYuZWangKet alCoumarin-Furoxan Hybrid Suppressed the Proliferation and Metastasis of Triple-Negative Breast Cancer by Activating Mitochondrial Stress and Cell Apoptosis