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Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

2 Results 2.1 Pharmacokinetic studies of BPC157 in rats The effective dose of BPC157 for the treatment of various injuries in mice, rats, and rabbits ranges from 6 to 50 g/kg ( The mean (+SD) plasma concentration of BPC157 versus time curves following administration of various BPC157 doses in rats are shown in Figures 1AC, and the corresponding pharmacokinetic parameters are presented in Tables 1Tables 3

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The localized and time-limited nature of angiogenic activity in wound healing models differs mechanistically from the sustained, dysregulated vascular recruitment characteristic of tumor growth

doi:10.4103/jrms.JRMS_862_18 De Bruyn E, Gulbis B, Cotton F

The peptide acts as a trigger