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Gene expression studies reveal modulation of 408 neuronal genes, including dramatic increases in OPRM1 (opioid receptor, up 1,294%), KCND1 (up 845%), and SLC8A2 (up 737%)

10.1039/c7mt00083a 6 BarrettC

Most patients feel a warmth and clarity during or after administration

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Finally, receptor-occupancy characterization in human tissue at clinically relevant exposures remains an open frontier that will likely be addressed in future publications